Recent & Upcoming Talks

2025

Containing Spillover with Minimal Supervision
Winner of 3rd place in the SPAR Symposium 2024 poster competition.
May 21, 2025
Ariana Azarbal, Matthew A. Clarke, Jorio Cocola, Cailley Factor, Alex Cloud
Project
Containing Spillover with Minimal Supervision

2024

Features that Fire Together Wire Together: Examining Co-occurence of SAE Features
Sparse autoencoders (SAE) aim to decompose activation patterns in neural networks into interpretable features. This promises to let us …
Oct 11, 2024
Matthew A. Clarke, Joseph Bloom
Project Video
Features that Fire Together Wire Together: Examining Co-occurence of SAE Features
Predicted combination treatments for NSCLC using in silico CRISPR screening
Lung cancer is the leading cause of cancer mortality world-wide, with over half of lung cancer patients relying on radiotherapy (RT). …
May 1, 2024 Kennedy Lecture Theatre, UCL Great Ormond Street Institute of Child Health
Matthew A. Clarke, Charles Barker, Ashley Nicholls, Matt Handler, Lisa Pickard, Saif Ahmad, Udai Banerji, Jyoti Choudhary, Gregory J. Hannon, Jasmin Fisher
Project Project Project
Predicted combination treatments for NSCLC using in silico CRISPR screening
Predicted combination treatments for NSCLC using in silico CRISPR screens
Lung cancer is the leading cause of cancer mortality world-wide, with over half of lung cancer patients relying on radiotherapy (RT). …
Feb 27, 2024 — Feb 28, 2024 The Discovery Centre,
Matthew A. Clarke, Charles Barker, Ashley Nicholls, Matt Handler, Lisa Pickard, Saif Ahmad, Udai Banerji, Jyoti Choudhary, Gregory J. Hannon, Jasmin Fisher
Project Project Project
Predicted combination treatments for NSCLC using in silico CRISPR screens
Predicting personalised treatment combinations with in silico CRISPR screens
Targeted therapies can be very effective in the short term, but often are stymied by resistance in the long term. We explore two …
Jan 29, 2024 — Jan 30, 2024 The Francis Crick Institute
Matthew A. Clarke
Project Project Project
Predicting personalised treatment combinations with in silico CRISPR screens

2023

Predicted radio-sensitising combination treatments for NSCLC using in-silico CRISPR screens
Lung cancer is the leading cause of cancer mortality world-wide, with over half of lung cancer patients relying on radiotherapy (RT). …
Nov 3, 2023 Cancer Research UK Cambridge Institute
Matthew A. Clarke, Ashley Nicholls, Charles Barker, Matt Handler, Saif Ahmad, Gregory J. Hannon, Jasmin Fisher
Project Project
Predicted radio-sensitising combination treatments for NSCLC using in-silico CRISPR screens
Targeted radio-sensitising combination treatments for NSCLC using in silico CRISPR screens
Lung cancer is the leading cause of cancer mortality world-wide, with over half of lung cancer patients relying on radiotherapy (RT). …
Oct 8, 2023 The Francis Crick Institute
Matthew A. Clarke, Ashley Nicholls, Charles Barker, Matt Handler, Saif Ahmad, Gregory J. Hannon, Jasmin Fisher
Project Project
Targeted radio-sensitising combination treatments for NSCLC using in silico CRISPR screens
Radiosensitising combination treatments for NSCLC using in silico CRISPR screens
Lung cancer is the leading cause of cancer mortality world-wide, and over half of lung cancer patients rely on radiotherapy (RT). …
Jun 30, 2023 Royal College of General Practitioners
Matthew A. Clarke, Ashley Nicholls, Matt Handler, Saif Ahmad, Gregory J. Hannon, Jasmin Fisher
Project Project
Radiosensitising combination treatments for NSCLC using in silico CRISPR screens
Radio-sensitising combination treatments for NSCLC using in silico CRISPR screens
Lung cancer is the leading cause of cancer mortality world-wide, and over half of lung cancer patients rely on radiotherapy (RT). …
Jun 19, 2023 Francis Crick Institute
Matthew A. Clarke, Ashley Nicholls, Matt Handler, Saif Ahmad, Gregory J. Hannon, Jasmin Fisher
Project Project
Radio-sensitising combination treatments for NSCLC using in silico CRISPR screens
Radio-sensitising combination treatments in NSCLC using in silico CRISPR screens
Lung cancer is the leading cause of cancer mortality world-wide, and over half of lung cancer patients rely on radiotherapy (RT). …
Jun 3, 2023 — Jun 6, 2023 University of Glasgow
Matthew A. Clarke, Ashley Nicholls, Matt Handler, Saif Ahmad, Gregory J. Hannon, Jasmin Fisher
Project Project
Radio-sensitising combination treatments in NSCLC using in silico CRISPR screens
Prediction of personalised therapies for triple-negative breast cancer using computational network modelling
May 17, 2023 Kennedy Lecture Theatre, UCL Great Ormond Street Institute of Child Health
Matthew A. Clarke, Ashley Nicholls, Steven Woodhouse, Klara Sinalova, Rashmi Kulkarni, Jean Abraham, Gregory J. Hannon, Graeme Hewitt, Jasmin Fisher
Project Project Project
Prediction of personalised therapies for triple-negative breast cancer using computational network modelling
Predicting personalised therapies for triple-negative breast cancer using computational network modelling
Feb 10, 2023 3:30 PM Clare College, University of Cambridge, UK
Matthew A. Clarke, Ashley Nicholls, Steven Woodhouse, Klara Sinalova, Rashmi Kulkarni, Jean Abraham, Gregory J. Hannon, Graeme Hewitt, Jasmin Fisher
Project Project
Predicting personalised therapies for triple-negative breast cancer using computational network modelling

2022

Executable biology: state-of-the-art methods to enable virtual crispr screens
Jun 14, 2022 9:30 AM The Francis Crick Insitute, London, UK
Matthew A. Clarke, Jasmin Fisher
Project Project Project
Executable biology: state-of-the-art methods to enable virtual crispr screens
Executable Network of SARS-CoV-2-Host Interaction Predicts Drug Combination Treatments
May 10, 2022 9:30 AM Woburn House, London, UK
Matthew A. Clarke, Rowan Howell, Ann-Kathrin Reuschl, Tianyi Chen, Sean Abbott-Imboden, Mervyn Singer, David M. Lowe, Clare L. Bennett, Benjamin Chain, Clare Jolly, Jasmin Fisher
Project
Executable Network of SARS-CoV-2-Host Interaction Predicts Drug Combination Treatments