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Tumor digital twins uncover therapeutic strategies in triple-negative breast cancer
Triple-negative breast cancer (TNBC) is an aggressive malignancy with limited therapeutic options and a high risk of relapse and …
Pedro Victori, Kui Hua, Alecia-Jane Twigger, Akanksha Anand, Zera M. Bose, Matthew A. Clarke, Steven Bell, Katrina J.Q. Xian, Lama Zakarneh, Karen Pinilla, Colin Y.C. Lee, Menna R. Clatworthy, Walid T. Khaled, Jean E. Abraham, PARTNER Trial Group, Personalised Breast Cancer Program Group, Gregory J. Hannon and Jasmin Fisher
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Tumor digital twins uncover therapeutic strategies in triple-negative breast cancer
Virtual Tumors Enable Prediction of Personalized Therapeutic Combinations for Non-Small Cell Lung Cancer
The disease burden from non-small cell lung cancer (NSCLC) adenocarcinoma is substantial, with a million new cases diagnosed globally …
Matthew A. Clarke, Charlie George Barker, Ashley Nicholls, Matt P. Handler, Lisa Pickard, Amna Shah, David Walter, Etienne De Braekeleer, Udai Banerji, Jyoti Choudhary, Saif Ahmed, Ultan McDermott, Gregory J. Hannon, Jasmin Fisher
PDF Project Project DOI
Virtual Tumors Enable Prediction of Personalized Therapeutic Combinations for Non-Small Cell Lung Cancer
Localized immune surveillance of primary melanoma in the skin deciphered through executable modeling
While skin is a site of active immune surveillance, primary melanomas often escape detection. Here, we have developed an in silico …
Rowan Howell, James Davies, Matthew A. Clarke, Anna Appios, Inês Mesquita, Yashoda Jayal, Ben Ringham-Terry, Isabel Boned Del Rio, Jasmin Fisher, Clare L. Bennett
PDF Dataset Project DOI
Localized immune surveillance of primary melanoma in the skin deciphered through executable modeling
HOXA9 has the hallmarks of a biological switch with implications in blood cancers
Blood malignancies arise from the dysregulation of haematopoiesis. The type of blood cell and the specific order of oncogenic events …
Laure Talarmain, Matthew A. Clarke, David Shorthouse, Lilia Cabrera-Cosme, David G. Kent, Jasmin Fisher, Benjamin A. Hall
PDF Code Dataset Project DOI
HOXA9 has the hallmarks of a biological switch with implications in blood cancers
Executable Network of SARS-CoV-2-Host Interaction Predicts Drug Combination Treatments
The COVID-19 pandemic has pushed healthcare systems globally to a breaking point. The urgent need for effective and affordable COVID-19 …
Rowan Howell, Matthew A. Clarke, Ann-Kathrin Reuschl, Tianyi Chen, Sean Abbott-Imboden, Mervyn Singer, David M. Lowe, Clare L. Bennett, Benjamin Chain, Clare Jolly, Jasmin Fisher
PDF Dataset Project DOI
Executable Network of SARS-CoV-2-Host Interaction Predicts Drug Combination Treatments
Executable cancer models: successes and challenges
Making decisions on how best to treat cancer patients requires the integration of different data sets, including genomic profiles, …
Matthew A. Clarke, Jasmin Fisher
PDF DOI
Executable cancer models: successes and challenges
Heterogeneity of Myc expression in breast cancer exposes pharmacological vulnerabilities revealed through executable mechanistic modeling
Cells with higher levels of Myc proliferate more rapidly and supercompetitively eliminate neighboring cells. Nonetheless, tumor cells …
Peter Kreuzaler, Matthew A. Clarke, Elizabeth J. Brown, Catherine H. Wilson, Roderik M. Kortlever, Nir Piterman, Trevor Littlewood, Gerard I. Evan, Jasmin Fisher
PDF Dataset Project DOI
Heterogeneity of Myc expression in breast cancer exposes pharmacological vulnerabilities revealed through executable mechanistic modeling