Matthew A. Clarke
Matthew A. Clarke
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Heterogeneity of Myc expression in breast cancer exposes pharmacological vulnerabilities revealed through executable mechanistic modeling
Cells with higher levels of Myc proliferate more rapidly and supercompetitively eliminate neighboring cells. Nonetheless, tumor cells …
Peter Kreuzaler
,
Matthew A. Clarke
,
Elizabeth J. Brown
,
Catherine H. Wilson
,
Roderik M. Kortlever
,
Nir Piterman
,
Trevor Littlewood
,
Gerard I. Evan
,
Jasmin Fisher
PDF
Dataset
Project
DOI
Using State Space Exploration to Determine How Gene Regulatory Networks Constrain Mutation Order in Cancer Evolution
Cancer develops via the progressive accumulation of somatic mutations, which subvert the normal operation of the gene regulatory …
Matthew A. Clarke
,
Steven Woodhouse
,
Nir Piterman
,
Benjamin A. Hall
,
Jasmin Fisher
PDF
Code
Dataset
Project
DOI
Predictive Computational Modelling of the c-myc Gene Regulatory Network for Combinatorial Treatments of Breast Cancer
As cancer tumours develop, competition between cells will favour those with some mutations over others, creating a dynamic …
Matthew A. Clarke
PDF
DOI
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