Breast Cancer

Triple-negative breast cancer (TNBC) is an aggressive malignancy with limited therapeutic options and a high risk of relapse and …

Computational models have become essential tools for understanding signalling networks and their non-linear dynamics. However, these …

Computatational modelling allows screening of thousands of combinations of drugs to find the most effective treatments. This allows for better protection against the emergence of resistance, as well as rapid drug repurposing e.g. to combat emerging diseases such as COVID-19.

Cancers evolve from normal cells, and continue to evolve to evade treatment. Understanding evolution from tumourigenesis will allow for earlier detection of cancer, while predicting evolution of resistance mechanisms is essential for finding treatments that are effective in the long term.

Cancers often emerge, in part, due to deficencies in DNA damage repair, making them vulnerable to DNA damaging treatments such as radiotherapy. While radiotherapy efficacy has been increasing, this is mainly due to better targeting of tumour anatomy, but targeted therapy offers the opportunity to radiosensitise tumour cells by targeting vulnerabilities in the tumour biology. We use computational modelling to find such vulnerabilities, and explore potential resistance mechanisms.

Cells with higher levels of Myc proliferate more rapidly and supercompetitively eliminate neighboring cells. Nonetheless, tumor cells …

Cancer develops via the progressive accumulation of somatic mutations, which subvert the normal operation of the gene regulatory …

As cancer tumours develop, competition between cells will favour those with some mutations over others, creating a dynamic …