DDR

Virtual Tumors Enable Prediction of Personalized Therapeutic Combinations for Non-Small Cell Lung Cancer
The disease burden from non-small cell lung cancer (NSCLC) adenocarcinoma is substantial, with a million new cases diagnosed globally …
Matthew A. Clarke, Charlie George Barker, Ashley Nicholls, Matt P. Handler, Lisa Pickard, Amna Shah, David Walter, Etienne De Braekeleer, Udai Banerji, Jyoti Choudhary, Saif Ahmed, Ultan McDermott, Gregory J. Hannon, Jasmin Fisher
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Virtual Tumors Enable Prediction of Personalized Therapeutic Combinations for Non-Small Cell Lung Cancer
DNA Damage Repair and Radiotherapy
Cancers often emerge, in part, due to deficencies in DNA damage repair, making them vulnerable to DNA damaging treatments such as radiotherapy. While radiotherapy efficacy has been increasing, this is mainly due to better targeting of tumour anatomy, but targeted therapy offers the opportunity to radiosensitise tumour cells by targeting vulnerabilities in the tumour biology. We use computational modelling to find such vulnerabilities, and explore potential resistance mechanisms.
Matthew A. Clarke
Clarke, Barker & Nicholls et al. (2026) Clarke, Barker & Nicholls et al. (2026)
DNA Damage Repair and Radiotherapy
Predicting personalised treatment combinations with in silico CRISPR screens
Targeted therapies can be very effective in the short term, but often are stymied by resistance in the long term. We explore two …
Jan 29, 2024 — Jan 30, 2024 The Francis Crick Institute
Matthew A. Clarke
Project Project Project
Predicting personalised treatment combinations with in silico CRISPR screens