Heterogeneity

Tumor digital twins uncover therapeutic strategies in triple-negative breast cancer
Triple-negative breast cancer (TNBC) is an aggressive malignancy with limited therapeutic options and a high risk of relapse and …
Pedro Victori, Kui Hua, Alecia-Jane Twigger, Akanksha Anand, Zera M. Bose, Matthew A. Clarke, Steven Bell, Katrina J.Q. Xian, Lama Zakarneh, Karen Pinilla, Colin Y.C. Lee, Menna R. Clatworthy, Walid T. Khaled, Jean E. Abraham, PARTNER Trial Group, Personalised Breast Cancer Program Group, Gregory J. Hannon and Jasmin Fisher
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Tumor digital twins uncover therapeutic strategies in triple-negative breast cancer
Virtual Tumors Enable Prediction of Personalized Therapeutic Combinations for Non-Small Cell Lung Cancer
The disease burden from non-small cell lung cancer (NSCLC) adenocarcinoma is substantial, with a million new cases diagnosed globally …
Matthew A. Clarke, Charlie George Barker, Ashley Nicholls, Matt P. Handler, Lisa Pickard, Amna Shah, David Walter, Etienne De Braekeleer, Udai Banerji, Jyoti Choudhary, Saif Ahmed, Ultan McDermott, Gregory J. Hannon, Jasmin Fisher
PDF Project Project DOI
Virtual Tumors Enable Prediction of Personalized Therapeutic Combinations for Non-Small Cell Lung Cancer
Heterogeneity of Myc expression in breast cancer exposes pharmacological vulnerabilities revealed through executable mechanistic modeling
Cells with higher levels of Myc proliferate more rapidly and supercompetitively eliminate neighboring cells. Nonetheless, tumor cells …
Peter Kreuzaler, Matthew A. Clarke, Elizabeth J. Brown, Catherine H. Wilson, Roderik M. Kortlever, Nir Piterman, Trevor Littlewood, Gerard I. Evan, Jasmin Fisher
PDF Dataset Project DOI
Heterogeneity of Myc expression in breast cancer exposes pharmacological vulnerabilities revealed through executable mechanistic modeling
Predictive Computational Modelling of the c-myc Gene Regulatory Network for Combinatorial Treatments of Breast Cancer
As cancer tumours develop, competition between cells will favour those with some mutations over others, creating a dynamic …
Matthew A. Clarke
PDF DOI
Predictive Computational Modelling of the c-myc Gene Regulatory Network for Combinatorial Treatments of Breast Cancer