Melanoma

Combination therapy
Computatational modelling allows screening of thousands of combinations of drugs to find the most effective treatments. This allows for better protection against the emergence of resistance, as well as rapid drug repurposing e.g. to combat emerging diseases such as COVID-19.
Matthew A. Clarke
Kreuzaler & Clarke et al. (2019) Kreuzaler & Clarke et al. (2019) Howell, Clarke & Reuschl et al. (2022) Howell, Clarke & Reuschl et al. (2022) Howell & Davies et al. (2023) Howell & Davies et al. (2023) Clarke, Barker & Nicholls et al. (2025)
Combination therapy
Localized immune surveillance of primary melanoma in the skin deciphered through executable modeling
While skin is a site of active immune surveillance, primary melanomas often escape detection. Here, we have developed an in silico …
Rowan Howell, James Davies, Matthew A. Clarke, Anna Appios, Inês Mesquita, Yashoda Jayal, Ben Ringham-Terry, Isabel Boned Del Rio, Jasmin Fisher, Clare L. Bennett
PDF Dataset Project DOI
Localized immune surveillance of primary melanoma in the skin deciphered through executable modeling