Cancer evolution
Matthew A. Clarke
Mar 8, 2023
Cancers evolve from normal cells, and continue to evolve to evade treatment. Understanding evolution from tumourigenesis will allow for earlier detection of cancer, while predicting evolution of resistance mechanisms is essential for finding treatments that are effective in the long term.
Image credit: Adapted from Niida et al., PeerJ 2020. CC-BY 4.0
Matthew A. Clarke
Research Fellow
Research Fellow at PIBBSS (Principles of Intelligent Behavior in Biological and Social Systems) working on mechanistic interpratibility of large language models with sparse autoencoders.
Publications
Blood malignancies arise from the dysregulation of haematopoiesis. The type of blood cell and the specific order of oncogenic events …
Laure Talarmain,
Matthew A. Clarke,
David Shorthouse,
Lilia Cabrera-Cosme,
David G. Kent,
Jasmin Fisher,
Benjamin A. Hall
Cancer develops via the progressive accumulation of somatic mutations, which subvert the normal operation of the gene regulatory …
Matthew A. Clarke,
Steven Woodhouse,
Nir Piterman,
Benjamin A. Hall,
Jasmin Fisher
Events
Lung cancer is the leading cause of cancer mortality world-wide, with over half of lung cancer patients relying on radiotherapy (RT). …
May 1, 2024
Kennedy Lecture Theatre, UCL Great Ormond Street Institute of Child Health
Matthew A. Clarke,
Charles Barker,
Ashley Nicholls,
Matt Handler,
Lisa Pickard,
Saif Ahmad,
Udai Banerji,
Jyoti Choudhary,
Gregory J. Hannon,
Jasmin Fisher
Lung cancer is the leading cause of cancer mortality world-wide, with over half of lung cancer patients relying on radiotherapy (RT). …
Feb 27, 2024 — Feb 28, 2024
The Discovery Centre,
Matthew A. Clarke,
Charles Barker,
Ashley Nicholls,
Matt Handler,
Lisa Pickard,
Saif Ahmad,
Udai Banerji,
Jyoti Choudhary,
Gregory J. Hannon,
Jasmin Fisher
Targeted therapies can be very effective in the short term, but often are stymied by resistance in the long term. We explore two …
Jan 29, 2024 — Jan 30, 2024
The Francis Crick Institute
Matthew A. Clarke
May 17, 2023
Kennedy Lecture Theatre, UCL Great Ormond Street Institute of Child Health
Matthew A. Clarke,
Ashley Nicholls,
Steven Woodhouse,
Klara Sinalova,
Rashmi Kulkarni,
Jean Abraham,
Gregory J. Hannon,
Graeme Hewitt,
Jasmin Fisher
Feb 10, 2023 3:30 PM
Clare College, University of Cambridge, UK
Matthew A. Clarke,
Ashley Nicholls,
Steven Woodhouse,
Klara Sinalova,
Rashmi Kulkarni,
Jean Abraham,
Gregory J. Hannon,
Graeme Hewitt,
Jasmin Fisher
Jun 14, 2022 9:30 AM
The Francis Crick Insitute, London, UK
Matthew A. Clarke,
Jasmin Fisher