DNA Damage Repair and Radiotherapy
CC-BY 4.0
Cancers often emerge, in part, due to deficencies in DNA damage repair, making them vulnerable to DNA damaging treatments such as radiotherapy. While radiotherapy efficacy has been increasing, this is mainly due to better targeting of tumour anatomy, but targeted therapy offers the opportunity to radiosensitise tumour cells by targeting vulnerabilities in the tumour biology. We use computational modelling to find such vulnerabilities, and explore potential resistance mechanisms.
Image credit: Adapted from Elbana et al. Front. Oncol 2021. CC-BY 4.0
Matthew A. Clarke
Research Fellow
Research Fellow at PIBBSS (Principles of Intelligent Behavior in Biological and Social Systems) working on mechanistic interpratibility of large language models with sparse autoencoders.
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